The research pursued in my lab is focused on the pre-B cell receptor (pre-BCR), a receptor expressed on precursor (pre-) B cells. This receptor is assembled from antibody (Ig) heavy chains and, instead of bona fide Ig light chains, the invariant surrogate light chain. Work from several groups including mine has shown that mutations that affect the expression of the pre-BCR may underpin the development of B cell immunodeficiency, systemic autoimmunity and leukaemia. The aim of my group's current research is to understand the underlying mechanisms that may result in such disparate diseases. We expect our results to increase our understanding of diseases, e.g. immunodeficiency, autoimmunity and cancer.
Mårtensson, I-L., Keenan, RA., and Licence, S 'The pre-B cell receptor' Current Opinion in Immunol. 19: 137-42 (2007)
Keenan RA, De Riva A, Corleis B, Hepburn L, Licence S, Winkler TH and Mårtensson I-L 'Censoring of Autoareactive B Cell Development by the Pre-B Cell Receptor' Science, 321:696-9 (2008)
Daly J, Licence S, Nanou K, Morgan, G. and Mårtensson, I-L 'Transcription of both the productive and non-productive VDJH-recombined allele after Ig heavy chain allelic exclusion' EMBO J 26: 4273-4282 (2007)
Parker, M.J., Licence, S., Erlandsson, L., Galler, G.R., Chakalova, L., Osborne, C.S., Morgan, G., Fraser, P., Jumaa, H., Winkler, T.H., Skok, J. and Mårtensson, I-L 'The pre-B-cell receptor induces silencing of VpreB and l5 transcription' EMBO J. 24:3895-3905 (2005)
Galler, R.G., Mundt, C., Parker, M, Mårtensson, I-L. and Winkler, T 'Surface m heavy chain signals downregulation of the V(D)J-recombinase machinery in the absence of surrogate light chain components' J. Exp. Med. 199:1523-1532 (2004)
Mundt, C., Licence, S., Shimizu, T., Melchers, F. and Mårtensson, I-L 'Loss of precursor B-cell expansion but not allelic exclusion in VpreB1/VpreB2-double deficient mice' J. Exp. Med. 193:435-446 (2001)